Cholinesterase inhibitors as Alzheimer's therapeutics (Review)
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چکیده
منابع مشابه
Alzheimer therapeutics-what after the cholinesterase inhibitors?
In the 1970s and early 1980s, biochemical and neuropathological evidence emerged, implicating the degeneration of basal forebrain acetylcholinergic neurons in Alzheimer’s disease (AD) [1]. The ‘cholinergic hypothesis’ of AD held that cholinergic dysfunction causes cognitive decline and that dementia therefore might be mitigated by the augmentation of acetylcholine activity in brain. The logical...
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Series of twenty-five benzyl (2S)-2-(arylcarbamoyl)pyrrolidine-1-carboxylates was prepared and completely characterized. All the compounds were tested for their in vitro ability to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), and the selectivity of compounds to individual cholinesterases was determined. Screening of the cytotoxicity of all the compounds was performed us...
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ژورنال
عنوان ژورنال: Molecular Medicine Reports
سال: 2019
ISSN: 1791-2997,1791-3004
DOI: 10.3892/mmr.2019.10374